| PREMARIN | | | | Now, what is estrogen? Estrogen is hormone whose |
| Premarin [conjugated estrogen] manufactured by | | | | secretion starts from the graffian follicle [which is |
| Wyeth Pharmaceuticals, is been marketed | | | | present in the ovaries] under the influence of Follicle |
| commercially since 1942. It is primarily used in treating | | | | Stimulating Hormone [FSH] and concentration in blood |
| post menopausal symptoms. | | | | rises gradually during follicular phase of the menstrual |
| But what exactly is Premarin? Premarin is a mixture of | | | | cycle. Due to the modest Follicle Stimulating Hormone |
| conjugated equine estrogens obtained exclusively from | | | | [FSH] surge, estrogens further rise transiently. After |
| natural sources, occurring as the sodium salts of | | | | ovulation, corpus luteum continues to secrete |
| water-soluble estrogen sulfates blended to represent | | | | estrogens till about two days before menstruation. |
| the average composition of material derived from | | | | Estrogens exercise feed back inhibition of Follicle |
| pregnant maresâ urine. It is a mixture of | | | | Stimulating Hormone-FSH [also Leutinizing Hormone at |
| sodium estrone sulfate and sodium equilin sulfate. It | | | | higher levels] by direct action on the pituitary gland as |
| contains as concomitant components, as sodium | | | | well as through hypothalamus. In post menopausal |
| sulfate conjugates, 17 ï¡-dihydroequilin, 17 | | | | women, there is a sharp decline in estrogen. |
| ï¡-estradiol, and 17 ï¢-dihydroequilin. | | | | |